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Thrombin receptor
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Thrombin receptor : ウィキペディア英語版
Thrombin receptor
There are three known thrombin receptors termed PAR1, PAR3 and PAR4 (PAR for protease-activated receptor).
These receptors are members of the 7 transmembrane g protein-coupled family of receptors, however, their method of activation is unique. Thrombin, a serine protease, binds to and cleaves the extracellular N-terminal domain of the receptor. A tethered ligand corresponding to the new N-terminus, SFLLRN, is then unmasked, binding to the second extracellular loop of the receptor and activating it.
==References==



抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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